Complex regulation of mucosal pentraxin (Mptx) revealed by discrete micro-anatomical locations in colon

Drew JE; Farquharson AJ; Keijer J; Barrera LN

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Complex regulation of mucosal pentraxin (Mptx) revealed by discrete micro-anatomical locations in colon

機(jī)譯：結(jié)腸中離散的微解剖位置揭示了對粘膜五聚蛋白（Mptx）的復(fù)雜調(diào)控

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Recently a mucosal pentraxin, Mptx, regulated by heme and calcium was reported in rat gut mucosal scrapings using microarray strategies. Considering the heterogeneity of gut mucosa scrapings and the widespread use of the rat as a model to study colon pathologies this study was undertaken to generate detailed mapping of micro-anatomical locations of Mptx and gain further insight into potential functions of this mucosal pentraxin in rat colon. Differential regulation was also examined in colon from different rat strains and rat models of oxidative stress and in pre-cancerous colon tissue. Different regional patterns of expression and discrete localisation in epithelial cells within transverse and distal colon crypts and an absence of expression in proximal colon were confirmed by regional PCR analysis and in situ hybridisation studies of colon. This study demonstrates that consideration of regional differences in Mptx gene expression and micro-anatomical location is necessary in the interpretation and deciphering of its regulation in colon. (c) 2006 Elsevier B.V. All rights reserved.

機(jī)譯：最近，使用微陣列策略在大鼠腸粘膜刮擦中報道了一種由血紅素和鈣調(diào)節(jié)的粘膜五肽毒素Mptx。考慮到腸粘膜刮擦的異質(zhì)性以及大鼠作為研究結(jié)腸病理模型的廣泛應(yīng)用，本研究旨在生成Mptx的微觀解剖部位的詳細(xì)圖譜，并進(jìn)一步了解該粘膜五聚體在大鼠結(jié)腸中的潛在功能。還檢查了來自不同大鼠品系和氧化應(yīng)激大鼠模型的結(jié)腸以及癌前結(jié)腸組織中的差異調(diào)節(jié)。通過結(jié)腸的區(qū)域PCR分析和結(jié)腸原位雜交研究，證實(shí)了橫結(jié)腸結(jié)腸遠(yuǎn)端和遠(yuǎn)端結(jié)腸隱窩中上皮細(xì)胞中表達(dá)的不同區(qū)域模式和離散定位以及近端結(jié)腸中不存在表達(dá)。這項(xiàng)研究表明，在解釋和解密其在結(jié)腸中的調(diào)控過程中，有必要考慮Mptx基因表達(dá)和微觀解剖位置的區(qū)域差異。（c）2006 Elsevier B.V.保留所有權(quán)利。

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《Biochimica et biophysica acta. Molecular basis of disease: BBA》 |2006年第9期|共5頁
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Drew JE; Farquharson AJ; Keijer J; Barrera LN;
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正文語種 eng
中圖分類生物工程學(xué)（生物技術(shù)）;
關(guān)鍵詞
colon crypt; gene regulation; epithelium; oxidative stress; pre-cancerous; C-REACTIVE PROTEIN; DIETARY HEME; RAT COLON;

機(jī)譯：結(jié)腸隱窩;基因調(diào)控;上皮細(xì)胞;氧化應(yīng)激;癌前;C反應(yīng)蛋白;飲食血紅素;大鼠結(jié)腸;

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機(jī)譯：鼠黏膜五聚蛋白（Mptx）蛋白的飲食調(diào)節(jié)和結(jié)構(gòu)預(yù)測以及人類功能喪失
7. Complex regulation of mucosal pentraxin (Mptx) revealed by discrete micro-anatomical locations in colon [O] . Drew Janice E., Farquharson Andrew J., Keijer Jaap, 2006

機(jī)譯：結(jié)腸中離散的微解剖位置揭示了對粘膜五聚蛋白（Mptx）的復(fù)雜調(diào)控

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Complex regulation of mucosal pentraxin (Mptx) revealed by discrete micro-anatomical locations in colon

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