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Remdesivir Treatment for COVID 19 in Pregnant Patients with Moderate to Severe Symptoms: Serial Case Report

機譯：妊娠患者患有中度至嚴重癥狀的妊娠患者的Remdesivir治療：序列案例報告

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Introduction: Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) infection that causes novel Coronavirus Disease 2019 (COVID-19) has become a major health problem worldwide and been declared a pandemic since March 2020 by WHO. One special population that poses a challenge is pregnant women with COVID-19. There have not been many studies related to COVID-19 in pregnancy. In this study, we present five serial cases of Remdesivir treatment for COVID-19 in pregnant women with moderate to severe symptoms. Case Illustration: We briefly describe five serial cases being treated with Remdesivir therapy during hospitalization. Four cases were delivered by cesarean section, and one was delivered vaginally in gestation week 37. All cases showed a shortened duration of hospitalization, rapid improvement in clinical symptoms, and no adverse events were observed in mothers, fetuses, and neonates. Discussion: Remdesivir, an inhibitor RNA Polymerase, has been used in COVID-19 treatment and is known to shorten recovery time in nonpregnant women. Some studies have shown no adverse effects on Remdesivir for pregnant women. Based on randomized control trial (RCT) during the Ebola epidemic, Remdesivir was safe to use for pregnant women. All cases showed reduced hospitalization time and better clinical outcomes without maternal, fetal, or neonatal adverse events. Conclusion: Remdesivir protocol for pregnant women with moderate to severe symptoms of COVID-19 has resulted in better clinical improvement with a shorter recovery period and no adverse effects during the hospitalization period. Further studies and RCT are warranted to evaluate the biosafety and effects of Remdesivir in pregnant women.
機譯：介紹：嚴重急性呼吸綜合征Corona病毒2（SARS-COV-2）導致新型冠狀病毒疾病2019（Covid-19）已成為全球主要的健康問題，并以自2020年3月以來一直宣布大流行。一個造成挑戰的一個特殊人口是孕婦有Covid-19。懷孕期間還沒有許多與Covid-19有關的研究。在這項研究中，我們在孕婦中展示了妊娠婦女的Covidiv治療的五個連續病例，中度至嚴重癥狀。案例說明：我們簡要描述了在住院期間用雷德爾治療治療的五種連續病例。四個病例由剖宮產分娩，一個人在妊娠周37中遞送了一個。所有病例均顯示出縮短的住院時間，臨床癥狀的快速提高，母親，胎兒和新生兒沒有觀察到不良事件。討論：RemdesiviR，抑制劑RNA聚合酶已用于Covid-19治療中，已知縮短在非妊娠女性中的恢復時間。有些研究表明對孕婦的雷德氏菌無否效應。基于埃博拉疫情期間的隨機對照試驗（RCT），雷德塞維爾對孕婦安全使用。所有病例均顯示出降低的住院時間和沒有母體，胎兒或新生兒不良事件的更好的臨床結果。結論：中度至嚴重癥狀的孕婦綜合癥方案較好的臨床改善，恢復期較短，在住院期間沒有不良反應。進一步的研究和rct是有必要評估孕婦中雷達爾的生物安全和影響。

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