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Chemical shift assignments and secondary structure prediction of the master biofilm regulator SinR from Bacillus subtilis

機譯：芽孢桿菌枯草芽孢桿菌的化學轉移分配和母料母膜穩壓器的二次結構預測

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Bacillus subtilis is a soil-dwelling Gram-positive bacterial species that has been extensively studied as a model of biofilm formation and stress-induced cellular differentiation. The tetrameric protein, SinR, has been identified as a master regulator for biofilm formation and linked to the regulation of the early transition states during cellular stress response, such as motility and biofilm-linked biosynthetic genes. SinR is a 111-residue protein that is active as a dimer of dimers, composed of two distinct domains, a DNA-binding helix-turn-helix N-terminus domain and a C-terminal multimerization domain. In order for biofilm formation to proceed, the antagonist, SinI, must inactivate SinR. This interaction results in a dramatic structural rearrangement of both proteins. Here we report the full-length backbone and side chain chemical shift values in addition to the experimentally derived secondary structure predictions as the first step towards directly studying the complex interaction dynamics between SinR and SinI.

機譯：枯草芽孢桿菌是一種居住在土壤中的革蘭氏陽性細菌，已作為生物膜形成和應激誘導的細胞分化的模型進行了廣泛研究。四聚體蛋白SinR已被確定為生物膜形成的主要調節劑，并與細胞應激反應（例如運動性和生物膜相關的生物合成基因）中早期過渡狀態的調節有關。 SinR是一種111殘基的蛋白質，可作為二聚體的二聚體起作用，由兩個不同的域組成：一個DNA結合螺旋-螺旋-螺旋N末端域和一個C端多聚域。為了使生物膜形成繼續進行，拮抗劑SinI必須使SinR失活。這種相互作用導致兩種蛋白質的戲劇性的結構重排。在這里，我們報告了全長骨架和側鏈化學位移值，以及通過實驗得出的二級結構預測，作為直接研究SinR和SinI之間復雜相互作用動力學的第一步。

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期刊名稱 other
作者
Sean D. Stowe; Andrew L. Olson; Richard Losick; John Cavanagh;
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作者單位

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年(卷),期 -1(8),1
年度 -1
頁碼 155–158
總頁數 6
原文格式 PDF
正文語種
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關鍵詞
NMR SinR Bacillus subtilis Biofilm regulation;

機譯：NMR;SinR;枯草芽孢桿菌;生物膜調節;

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1. Chemical shift assignments and secondary structure prediction of the master biofilm regulator, SinR, from Bacillus subtilis [J] . Sean D. Stowe, Andrew L. Olson, Richard Losick, Biomolecular NMR assignments . 2014,第1期

機譯：枯草芽孢桿菌中主要生物膜調節劑SinR的化學位移分配和二級結構預測
2. The Solution Structures and Interaction of SinR and Sinl: Elucidating the Mechanism of Action of the Master Regulator Switch for Biofilm Formation in Bacillus subtilis [J] . Milton Morgan E., Draughn G. Logan, Bobay Benjamin G., Journal of Molecular Biology . 2020,第2期

機譯：SINR和SINL的溶液結構和相互作用：闡明Bacillus枯草芽孢桿菌的生物膜形成母穩壓器開關的作用機理
3. Selective Pressure for Biofilm Formation in Bacillus subtilis: Differential Effect of Mutations in the Master Regulator SinR on Bistability [J] . Jan Kampf, Jan Gerwig, Kerstin Kruse, MBio . 2018,第5期

機譯：在枯草芽孢桿菌中形成生物膜的選擇壓力：主調節劑SinR中的突變對雙穩性的不同影響
4. Isolation and chemical characterization of the extracellular polysaccharide required for biofilm formation in Bacillus subtilis [C] . AHMED HUSSEIN, Daniel Kearns, Yehia Mechref, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

機譯：枯草芽孢桿菌生物膜形成所需的細胞外多糖的分離和化學表征
5. The Structures of Biofilm-Controlling Proteins from Acinetobacter baumannii and Bacillus subtilis Reveal Details of DNA-binding Mechanisms and Illuminate Potential Therapeutic Targets. [D] . Draughn, George Logan. 2017

機譯：鮑曼不動桿菌和枯草芽孢桿菌的生物膜控制蛋白的結構揭示了DNA結合機制的細節，并闡明了潛在的治療靶標。
6. Structure and Organisation of SinR the Master Regulator of Biofilm Formation in Bacillus subtilis [O] . Vicki L. Colledge, Mark J. Fogg, Vladimir M. Levdikov, -1

機譯：SinR的結構和組織枯草芽孢桿菌生物膜形成的主要調控者
7. Structure and Organisation of SinR, the Master Regulator of Biofilm Formation in Bacillus subtilis [O] . Colledge, Vicki L., Fogg, Mark J., Levdikov, Vladimir M., 2011

機譯：SinR的結構和組織，枯草芽孢桿菌生物膜形成的主要調控者

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Chemical shift assignments and secondary structure prediction of the master biofilm regulator SinR from Bacillus subtilis

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