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Development of nanofluidic/microfluidic interfaces as analyte concentrators for proteomic samples.

機(jī)譯：納米流體/微流體界面作為蛋白質(zhì)組學(xué)樣品的分析物濃縮器的開發(fā)。

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We have developed a nanofluidic microfluidic analyte concentrator for application to proteomic samples. This dissertation includes a study investigating the current rectification behavior of the device including a temporal characterization of the ON state to OFF state transition and the OFF state to ON state transition as a function of device design. An analyte concentrator compatible with proteomic samples is presented and the current rectifying phenomenon is utilized to ensure adequate analyte delivery for the enrichment process. Finally, characterization of a coating technique to alter the surface charge of the nanofluidic element from anionic to cationic is presented.

機(jī)譯：我們已經(jīng)開發(fā)出一種用于蛋白質(zhì)組學(xué)樣品的納米流體微流體分析物濃縮儀。本論文包括研究器件的當(dāng)前整流行為的研究，包括根據(jù)器件設(shè)計(jì)將導(dǎo)通狀態(tài)轉(zhuǎn)換為關(guān)斷狀態(tài)以及從關(guān)斷狀態(tài)轉(zhuǎn)換為導(dǎo)通狀態(tài)的時(shí)間特性。提出了與蛋白質(zhì)組學(xué)樣品兼容的分析物濃縮器，并利用當(dāng)前的整流現(xiàn)象來(lái)確保為富集過(guò)程提供足夠的分析物。最后，介紹了將納米流體元件的表面電荷從陰離子改變?yōu)殛?yáng)離子的涂層技術(shù)的表征。

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Reschke, Kathleen C.;
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West Virginia University.;

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授予單位 West Virginia University.;
學(xué)科 Chemistry Analytical.;Chemistry Biochemistry.
學(xué)位 Ph.D.
年度 2010
頁(yè)碼 136 p.
總頁(yè)數(shù) 136
原文格式 PDF
正文語(yǔ)種 eng
中圖分類
關(guān)鍵詞

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1. Investigation of Zone Migration in a Current Rectifying Nanofluidic/Microfluidic Analyte Concentrator [J] . Kathleen C. Kelly, Scott A. Miller, Aaron T. Timperman Analytical chemistry . 2009,第2期

機(jī)譯：電流整流納米流體/微流體分析物濃縮器中區(qū)域遷移的研究
2. Analyte transport past a nanofluidic intermediate electrode junction in a microfluidic device [J] . Xiuli Mao Brent R. Reschke Aaron T. Timperman ELECTROPHORESIS . 2010,第15期

機(jī)譯：分析物通過(guò)微流體裝置中的納米流體中間電極結(jié)傳輸
3. Analyte transport past a nanofluidic intermediate electrode junction in a microfluidic device. [J] . Mao X, Reschke BR, Timperman AT Electrophoresis: The Official Journal of the International Electrophoresis Society . 2010,第15期

機(jī)譯：分析物通過(guò)微流控設(shè)備中的納米流體中間電極接合處傳輸。
4. Label-free direct detection of biomolecular analytes from optically inaccessible samples. [C] . Louis.C. Brousseau, Karen Lee Brown Nanotech Conference Expo . 2009

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5. Development of microfluidic modules for DNA purification via phenol extraction and analyte concentration using transverse electrokinetics. [D] . Morales, Mercedes C. 2012

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6. Silicon Nanofluidic Membrane for Electrostatic Control of Drugs and Analytes Elution [O] . Nicola Di Trani, Antonia Silvestri, Yu Wang, 2020

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7. Development of nanofluidic/microfluidic interfaces as analyte concentrators for proteomic samples [O] . Kathleen C. Reschke -1

機(jī)譯：納米流體/微流體界面的開發(fā)作為蛋白質(zhì)組學(xué)樣品的分析物濃縮器

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Development of nanofluidic/microfluidic interfaces as analyte concentrators for proteomic samples.

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